Citicoline Protects Against Cognitive Impairment in a Rat Model of Chronic Cerebral Hypoperfusion
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چکیده
منابع مشابه
ERRATUM: Citicoline Protects Against Cognitive Impairment in a Rat Model of Chronic Cerebral Hypoperfusion
[This corrects the article on p. 33 in vol. 5, PMID: 19513332.].
متن کاملCiticoline Protects Against Cognitive Impairment in a Rat Model of Chronic Cerebral Hypoperfusion
BACKGROUND AND PURPOSE Cerebral white matter (WM) lesions are frequently observed in human cerebrovascular diseases, and are believed to be responsible for cognitive impairment. Various neuroprotective agents can suppress this type of WM or neuronal damage. In this study, we investigated whether citicoline, a drug used to treat acute ischemic stroke, can attenuate WM lesions and cognitive decli...
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Chronic cerebral hypoperfusion (CCH) is one of the most common causes of vascular dementia (VaD) and is recognised as an etiological factor in the development of Alzheimer's disease (AD). CCH can induce severe cognitive deficits, as assessed by the water maze task, along with neuronal loss in the hippocampus. However, there are currently no effective, approved pharmacological treatments availab...
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BACKGROUND AND PURPOSE White matter lesions contribute to cognitive impairment in poststroke patients. The present study was designed to assess the neuroprotective mechanisms of cilostazol, a potent inhibitor of type III phosphodiesterase, through signaling pathways that lead to activation of transcription factor cAMP-responsive element binding protein (CREB) phosphorylation using rat chronic c...
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Chronic cerebral hypoperfusion (CCH), featuring in most of the Alzheimer's disease spectrum, plays a detrimental role in brain amyloid-β (Aβ) homeostasis, cerebrovascular morbidity, and cognitive decline; therefore, early management of cerebrovascular pathology is considered to be important for intervention in the impending cognitive decline. S-nitrosoglutathione (GSNO) is an endogenous nitric ...
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ژورنال
عنوان ژورنال: Journal of Clinical Neurology
سال: 2009
ISSN: 1738-6586
DOI: 10.3988/jcn.2009.5.1.33